Association of Tongue Bacterial Flora and Subtypes of Liver-Fire Hyperactivity Syndrome in Hypertensive Patients
نویسندگان
چکیده
Structural changes in symbiotic human microorganisms can affect host phenotype. Liver-fire hyperactivity syndrome (LFHS) presents as bitter taste, halitosis, xerostomia, odontalgia, and other oral symptoms. LFHS is associated with hypertension (EH). In this study, tongue flora was analyzed to further understand the intrinsic relationship between tongue flora and LFHS. Samples of tongue coating, from 16 patients with EH-LFHS, 16 with EH-non-LFHS, and 16 controls, were obtained; then, 16S rRNA variable (V3-V4) regions were amplified and sequenced by MiSeq PE300 Sequencing. Tag clustering and Operational Taxonomic Units (OTUs) abundance analysis were used to compare the OTU sequence with the 16S database. The species were classified, and diversity and structure of the bacterial flora were compared between the three groups. Alpha diversity analysis, including Observed Species index and Chao index, indicated significantly higher richness of species in patients with EH-LFHS (p < 0.05). Higher phylogenetic diversity, in patients with EH-non-LFHS, indicates greater differences in evolutionary history than in patients with EH-LFHS. Streptococcus, Rothia, Neisseria, and Sphingomonas were the most prevalent in patients with EH-LFHS, differed from the other two groups. This indicates that richer bacterial diversity, and structure associated with EH-LFHS, may affect the occurrence, development, and outcome of hypertension and syndrome subtypes recognized by TCM.
منابع مشابه
Prevalence of geographic tongue and its association with other cutaneous diseases in patients referred to the Dermatology Clinic of Tehran Razi Hospital in 1997
Background: Geographic tongue is an inflammatory disorder of unknown etiology that affects the epithelium of the tongue. It has been associated with several cutaneous diseases. Objective: To determine the prevalence of geographic tongue and its association with other cutaneous diseases in patients referred to the dermatology clinic of Razi hospital. Patients and methods: A cross-sectional study...
متن کاملHow Probiotic Reduce Symptoms of Irritable Bowel Syndrome?
Introduction: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder in children that may lead to anxiety, frequent physician visits and school absenteeism. The aim of this study is to reviewe effects of probiotic for irritable bowel syndrome. Materials and Methods: This study review articles about probiotic for irritable bowel syndrome in pubmed and google scholar. Results: M...
متن کاملDifference in histological subtypes of basal cell carcinoma according to age, gender, location, mitotic activity and association with solar keratoses
Background and aim: Basal cell carcinoma (BCC) is the most common skin cancer in white-skin populations. Recent studies suggest that BCC is not a single entity and different histological subtypes show different clinical behavior and might have different etiology. The aim of this study was to assess differences in age, sex, site of distribution and proliferative activity in histological subtypes...
متن کاملبیسموت ساب‌سیترات در بهبود علایم بیماران مبتلا به سندرم روده تحریک‌پذیر با علامت غالب اسهال
Background: The irritable bowel syndrome (IBS) is one of the most common chronic medical conditions. Various mechanisms, including altered gut flora and/or small bowel bacterial overgrowth, have been suggested to play a role in the development of gas-related symptoms aim of study. The clinical evidence of small intestinal bacterial overgrowth as an important etiology of irritable bowel syndrome...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2018 شماره
صفحات -
تاریخ انتشار 2018